the Internet has many of us on a very short leash – an addictive one.

Whether you’re mid-bite, mid-sentence or perhaps mid-sleep, do you react to that ‘bing’ from your smartphone? Or, is it the flashing red light that gets you?

You’ve programmed your phone to alert you to messages, or has it programmed you to respond?

From the constant smartphone companion to the laptop replacing the lapdog, the Internet has many of us on a very short leash – an addictive one.

The consumer research firm Intersperience surveyed more than 1,000 people in Britain and found quitting the Internet is as hard for some as quitting drinking or smoking.

Without the Internet, 40% said they felt lonely. Ironically, it’s fathomable that 40% of those living with Internet addicts probably feel lonely too.

Laurie Tamblyn, an addictions counsellor in special programs at Toronto’s Bellwood Health Services, says there are many types of Internet addiction, including gambling, gaming, pornography and social networking.

“We’re just beginning to treat this. It is a big problem and it is going to become bigger before people start recognizing that they need to do something about it,” Tamblyn says.

“Some of us believe there is a tsunami coming because we haven’t fully recognized the problem yet.”

Part of that problem is the generation gap. Children today are children of technology – dependent on the social web and its tools.

Addiction is a progressive illness that ends up in isolation, Tamblyn says, so Internet use can be a slippery slope, and can have devastating effects on relationships.

“The amount of time people spend lost in their behaviours is comparable to a drinker spending time at the bar instead of with his family or friends,” Tamblyn says.

“The addiction becomes the focus of the addict’s life. The focus is to interact with the addiction before anything else. If this doesn’t happen, it results in mood swings and irritability.”

Internet addiction can be difficult to diagnose, says Dr. Greg Dubord, who teaches in the psychiatry department at the University of Toronto.

“Drawing the line between normal Internet use and Internet addiction is often difficult, because no set criteria for diagnosing the disorder have been established by the American Psychiatric Association.”

What is easy to recognize, however, is the impact of web overuse on our relationships.

Though social networking allows us to communicate with people all over the world, at times it seems to segregate us more than ever. Real-life interaction is often interrupted by bings and beeps. Thoughts become tweets and e-mails. Our fingers do the walking and the talking now.

From neglecting friends and family members to creating severe relationship problems, the Internet and our attachment to it can consume our lives.

One study documents 396 negative effects of the web on social involvement, including significant family problems, Dubord says.

“Reports have shown that excessive use of the Internet resulted in personal and family problems, with 53% of test-takers reporting severe relationship problems,” he says.

“Personal and family concerns extended to marriages, dating relationships, parent-child relationships, and close friendships.”

Dubord notes one case where a New York woman divorced her husband due to Internet overuse, and an extreme case involving a Korean couple so addicted to virtual games they let their three-month-old daughter starve to death.

If you think you may have a problem, Tamblyn says the best thing to do is ask for help.

“You can get an assessment at any treatment centre, or do it online and it’s anonymous. There are a lot of people struggling, and there’s a lot of help.”

Too e-dependent? Greg Dubord points out some general warning signs:

1. Lose track of time online.

2. Failed attempts at moderating Internet behaviour.

3. Neglecting work, sleep, friends and/or family to spend time online.

4. Turning to the Internet in times of stress or sadness to feel better.

How to cut down, according to Laurie Tamblyn:

1. Give yourself short breaks throughout the day when you can’t check your messages. Try going for a walk without your smartphone.

2. Put your iPad to bed. Set a bedtime for your Internet devices.

3. Wi-Fi-free meals. Wash your hands of wireless devices before eating.

4. Put your computer in a high-traffic area to stay accountable to those around you.

Italy government hangs by thread as coalition crumbles

 

Italian Prime Minister Silvio Berlusconi's fate hung by a thread Friday and desertions from his crumbling centre-right coalition may have already robbed him of the parliamentary numbers he needs to survive. Berlusconi, caught in the crossfire from European powers and a party revolt at home, agreed at a G20 summit in France to IMF monitoring of economic reforms which he has long promised but failed to implement. But this may soon be irrelevant for the Italian leader, who will return to Rome later Friday to face what looks increasingly like a deadly rebellion by his own supporters. With financial markets in turmoil over the situation in Greece and Italy viewed as the next domino to fall in the euro zone crisis, calls are mounting for a new government to carry through reforms convincing enough to regain international confidence. Berlusconi has consistently rejected calls to resign and says the only alternative to him is an early election next spring, rather than the technocrat or national unity government urged by many politicians and commentators. Yields on 10-year Italian bonds reached 6.36 percent by early afternoon, creeping closer to 7 percent, a level which could trigger a so-called "buyers' strike" where investors take fright and refuse to buy the paper. Two deputies from Berlusconi's PDL party this week defected to the centrist UDC, taking his support in the 630-seat lower house of parliament to 314 compared with the 316 he needed to win a confidence vote last month. But at least seven other former loyalists have called for a new government and could vote against the 75-year-old media magnate. "The (ruling) majority seems to be dissolving like a snowman in spring," said respected commentator Stefano Folli in the financial daily Il Sole 24 Ore. Other commentators spoke of an "inexorable" revolt against Berlusconi. Even Defence Ministry undersecretary Guido Crosetto, a Berlusconi loyalist, said on television: "I don't know how many days or weeks the government has left. Certainly a majority relying on a few votes cannot continue for long." PATRONAGE Berlusconi, one of Italy's richest men, still has significant powers of patronage and he and his closest aides are expected to spend the weekend trying to win back support for a parliamentary showdown Tuesday. Some rebels have already threatened to vote against Berlusconi in the vote to sign off on the 2010 budget. Berlusconi faced concerted calls to resign when he lost a previous vote on this routine measure, which was almost unprecedented. Although it is not a confidence motion, he would come under huge pressure if he suffered a second defeat. "Unpopular prescriptions are necessary and this challenge cannot be faced with a 51 percent government," said UDC leader Pier Ferdinando Casini, in a reference to Berlusconi's weakness and a widespread feeling that the reforms can only be passed with a broad consensus. The premier has promised European leaders that he will call a formal confidence motion within 15 days to pass amendments to a budget bill incorporating new measures to stimulate growth and cut Italy's huge debt. That will be in the Senate where he has a more solid majority but it could still bring him down. Berlusconi, beset by a string of sex scandals and court cases, has consistently resisted pressure from groups ranging from a powerful business lobby to the Catholic Church to stand down.

COLOMBIAN lingerie model dubbed "Narco Queen" was handed six years in jail

 

COLOMBIAN lingerie model dubbed "Narco Queen" was handed six years in jail yesterday after trying to ship cocaine to Europe in her suitcases. Stunning Angie Sanclemente Valencia, 31, had denied helping her boyfriend recruit other beautiful young women to work for her international drug smuggling ring. The former beauty queen tried to take drugs from Argentina to Europe in late 2009 via Mexico. She was arrested in Buenos Aires, Argentina, in May 2010 after months on the run from police. Her attorney German Delgado said he would appeal the conviction. He insisted there was no proof, declaring that Sanclemente should be acquitted as she had no criminal record. Nicolas Gualco, her boyfriend, was also sentenced to six years and eight months for his role in the same plot. Sanclemente claimed during the trial in Argentina that she travelled to the country to marry Gualco and was not involved in the drug trade. She told the court: "I did not come here to commit crimes, I am not a narco-trafficker." She said all she had done for her boyfriend was "make a few calls", adding: "God knows I did it for love." Another man, Venezuelan Gustavo Paez Arneses, was sentenced to six years and two months for his role in the smuggling attempt.

Addicts may have glitch in frontal brain

 

“The better we understand our decision-making brain circuitry, the better we can target treatment, whether it’s pharmaceutical, behavioral, or deep brain stimulation,” says Jonathan Wallis, associate professor of psychology and neuroscience at University of California, Berkeley. Wallis says he was inspired to study the brain mechanism behind substance abuse after observing the lengths to which an addict will go to fulfill a craving, despite knowing the downside of a habit. He wanted to know what the drug did to the brain that made it so difficult to not make the right choice and what prevented the addict from making a healthier one. Straight from the Source Read the original study DOI: 10.1038/nn.2961 In the new study, published in Nature Neuroscience, Wallis targeted the orbitofrontal cortex and anterior cingulate cortex—two areas in the frontal brain—because previous research has shown that patients with damage to these areas of the brain are impaired in the choices they make. While these individuals may appear perfectly normal on the surface, they routinely make decisions that create chaos in their lives. A similar dynamic has been observed in chronic drug addicts, alcoholics, and people with obsessive-compulsive tendencies. “They get divorced, quit their jobs, lose their friends, and lose all their money,” Wallis says. “All the decisions they make are bad ones.” To test the hypothesis that these areas of the brain are the key players in impaired decision-making, researchers measured the neural activity of macaque monkeys as they played games in which they identified the pictures most likely to deliver juice through a spout into their mouths. The animals quickly learned which pictures would most frequently deliver the greatest amount of juice, allowing researchers to see what calculations they were making, and in which part of the brain. The brains of macaques function similarly to those of humans in basic decision making. The exercise was designed to see how the animals weigh costs, benefits, and risks. The results show that the orbitofrontal cortex regulates neural activity, depending on the value or “stakes” of a decision. This part of the brain enables you to switch easily between making important decisions, such as what school to attend or which job to take, and making trivial decisions such as coffee versus tea or burrito versus pizza. But in the case of addicts and people with damage to the orbitofrontal cortex, the neural activity does not change based on the gravity of the decision, presenting trouble when these individuals try to get their brains in gear to make sound choices, the findings suggest. As for the anterior cingulate cortex, the study found that when this part of the brain functions normally, we learn quickly whether a decision we made matched our expectations. If we eat food that makes us sick, we don’t eat it again. But in people with a malfunctioning anterior cingulate cortex, these signals are missing, and so they continue to make poor choices, Wallis says. “This is the first study to pin down the calculations made by these two specific parts of the brain that underlie healthy decision-making,”  Wallis says, who believes that a clearer understanding of how people with addictions make decisions may help remove some of the stigma of the condition. However, Wallis warned that the findings should not be used as a rationale for addicts to maintain unhealthy habits. Chronic drug and alcohol use changes the brain circuitry, and that can lead to unhealthy choices, he says. If anything, the findings offer hope that, through understanding the mechanism of addiction, treatment can be targeted at these risk-weighing, decision-making centers of the brain. “We know beyond doubt that addiction is a complex brain disease with significant behavioral characteristics,” says Susan E. Foster, vice president and director of policy research and analysis at the National Center on Addiction and Substance Abuse at Columbia University. “This research is an important contribution to understanding how the disease works. The challenge going forward is to sharpen our understanding, translate this knowledge into effective medical treatments and new prevention strategies and ultimately find a cure for this disease.” Researchers from the University of London and the University of Oxford contributed to the study that was funded by the National Institute on Drug Abuse.

Chief Superintendent Mark Mathias from South Wales Police said: "Each addict can cost society not far off £850,000

Heroin addicts cost society £850,000 each, police warn
Photo: PA

Top officers warned of the increasing cost of drug-ravaged society with hundreds of millions is being spent on the increasing number of addicts.

Chief Superintendent Mark Mathias from South Wales Police said: "Each addict can cost society not far off £850,000.

"You work through all the treatment, all the criminal justice issues that arise - then you see a significant costs involved."

Police in Swansea have launched a £500,00 clampdown in the city known as the "heroin capital of Wales" where officers have seized 1,000 "deals" in the last two weeks.

Superintendent Phil Davies said: "Some of these drug dealers have stated they are untouchable.

"My message to them is there is no hiding place, we will find you, we will catch you and we will put you behind bars."

Addict Amy Protheroe, 20, who has been an addict since she was 13 has just started her fifth treatment programme in Swansea.

She said: "When you're a heroin addict you wake up and you think straight away: "Where am I going to get money from, where am I going to score from?'"

"You get up, you go out, you get the money for the heroin, you buy the heroin, you do the heroin and then it starts all over again.

"To be honest, heroin has wrecked my life."

charity worker employed by one of David Cameron’s Big Society gurus has been arrested on suspicion of smuggling cocaine with a street value of £120,000

charity worker employed by one of David Cameron’s Big Society gurus has been arrested on suspicion of smuggling cocaine with a street value of £120,000 into Britain.

Former US gang member Derrick ‘Anthony’ Mitchell was held at Heathrow this month after UK Border Agency officers allegedly discovered 3kg of drugs in his luggage. 

Mitchell, 37, is a duty manager at the South London-based Kids Company founded by charity boss Camila Batmanghelidjh. She set it up in 1996 to care for abused, neglected or  abandoned children in London’s inner-city communities. 

She has been described as ‘Britain’s most colourful charity leader’ because of her style, dress sense and selfless approach to charity work. 

The award-winning author and campaigner was invited  to 10 Downing Street last year. 

She also advises former Tory leader Iain Duncan Smith and is thought to be one of the inspirations behind Mr Cameron’s pledge to ‘hug a hoodie’. 
Ms Batmanghelidjh spoke of her shock at the allegations surrounding Mr Mitchell, whom  she described as a ‘street-level youth mentor’.

She said: ‘Obviously, because the judicial process needs to take place, we cannot legally comment. The only thing I can say is that the alleged incident took place while he was on holiday in his own time.

‘At this stage I do not know enough to know the full details. But as a worker, he gave exceptional commitment to the kids over a number of years and I can never take that away from him. 

Pledge: David Cameron's Big Society aims to 'take power away from politicians and give it to people'

Pledge: David Cameron's Big Society aims to 'take power away from politicians and give it to people'

As an organisation, we employ a range of people and a lot of them have had challenging backgrounds as children and we have given them chances. The majority of them go on to do incredibly well.

‘In the situation of this individual, if what is alleged has occurred, he has made an abhorrent choice and I do not agree with it.’ 

Camila Batmanghelidjh said she was shocked at the allegations surrounding Mr Mitchell, claiming he gave 'exceptional commitment to the kids'

Camila Batmanghelidjh said she was shocked at the allegations surrounding Mr Mitchell, claiming he gave 'exceptional commitment to the kids'

Mitchell, of Camberwell, south London, was arrested at Heathrow on October 6 and remanded in custody by Uxbridge magistrates the next day. He will reappear in court in the next month. 

The university undergraduate has previously spoken of deciding to rebuild his life after leaving a violent street gang in Miami.

He claimed he had earlier sold drugs and lost a family member to violence at the age of 19 when his sister bled to death after being stabbed in a leg.

After coming to Britain in his 20s, he began working with the charity about five years ago, attempting to convince youths in gangs to turn their back on crime. 

Kids Company operates from three centres in Southwark, Lambeth and Camden in London, as well as working in 37 inner-city schools.

It employs more than 600 people in full and part-time roles to reach out to 14,000 children from the capital’s most deprived and crime-ridden areas. 

Many of the youngsters live with  parents who are unable to care  for them and have had severely troubled lives.



Chicago area had the most heroin-related hospital visits in the nation.

 

2010 study by Roosevelt University researchers found the Chicago area had the most heroin-related hospital visits in the nation. The drug is cheap, and it's attracting users everywhere including some who are very young. Today's heroin can be snorted or smoked -- not just injected -- and that's led to a change in the typical user. Increasingly, today's addict is young, female and from the suburbs. And the roots of their addiction can be found in their family's medicine cabinet. For many, the road to dependence begins at independence --one of a handful of West Side exits off the Eisenhower serve as the gateway to the nation's busiest heroin corridor. "The ride there you're just anxiety, just, 'Oh I can't wait to get there. I can't wait to get it. I can't wait to feel better,'" said a 19-year-old female heroin addict whose scar are more than skin deep. She grew up far from the west side's rough and tumble streets, amidst the manicured lawns of the far west suburbs which seems an unlikely breeding ground for a new crop of heroin users. "I always thought of them as homeless and not caring about what they look like and real skinny and everything," the 19-year-old addict said. Heroin has never been cheaper and more pure. Just $100 can buy a two day supply. "I knew. The first time I did it I was like, 'This is bad. I like this way too much. And this is going to be bad," said the 19-year-old addict, whose identity ABC7 has hidden. DEA Agent Jack Riley says powerful Mexican drug cartels have partnered with Chicago street gangs to make heroin easily available. "If I had to liken anything to a weapon of mass destruction, it would be heroin," Riley said. After smuggling the drugs here, Riley says the cartels often operate in Spanish-speaking areas near Midway Airport. "They can assimilate into these hard working neighborhoods. They can appear to be great citizens, take care of their lawn, put Christmas lights up," Riley said. The cartels need the gangs to distribute the drugs but officials say fights between the two groups are increasingly to blame for the near-daily violence plaguing some neighborhoods. "What we consider to be senseless violent acts, many of them may be actually connected to the cartel's operations in Chicago," Riley said. It seems the danger is of little deterrent to users. "Within two weeks I was getting sick physically without it, and I needed it," the 19-year-old addict said. It wasn't until an overdose nearly killed her that she began treatment a few weeks ago at New Hope Recovery Center in Geneva. In four years, the facility has seen a seven-fold increase in heroin cases and many involve teens first hooked on prescription painkillers. "They'll run out, and someone will say 'Well, snort some heroin. It'll help you, so you won't go through withdrawals,'" said Jake Epperly, New Hope Recovery Center. That may have been how Billy Roberts began using. The Homer Glen 19-year-old died of an overdose two years ago and his father now warns of heroin's dangers. "I do it for him," said the victim's father John Roberts. "And I'll continue doing it as long as I'm alive. To give my son's life meaning. A former Chicago cop, Roberts says it's time for new solutions. "We need help. The police cannot do this alone. We need a comprehensive, strategic approach to this problem if we're ever going to see these numbers turn downward," Roberts said. To put in perspective how big the problem is here, the Chicago DEA has secured funding for a 90-person strike force to combat the operation run by the cartels and gangs in the city. Officials say it's the only such strike force outside of the U.S.-Mexico border. The 19-year-old woman interviewed by ABC7, who is currently in treatment, says she knows at least 20 other kids her age, from her community, who are current or former users.

Roxies sell on the street for as much as $30 per pill and offer a high that tops crack, heroin or meth

Michael Patrick/news sentinel The two most wanted prescription pills on the streets of East Tennessee. The small pills are Roxie 30 and the large green pill is an Oxycontin 80. The second-generation Oxys, made by Purdue Pharma, are now wrapped in a sticky gelcap coating that will burn nostrils and resists needles.

PHOTO BY MICHAEL PATRICK, COPYRIGHT © 2011 // BUY THIS PHOTO

Michael Patrick/news sentinel The two most wanted prescription pills on the streets of East Tennessee. The small pills are Roxie 30 and the large green pill is an Oxycontin 80. The second-generation Oxys, made by Purdue Pharma, are now wrapped in a sticky gelcap coating that will burn nostrils and resists needles.

Effects of oxycodone: The high caused by oxycodone and other opiates affects nearly every major organ in the human body. So does withdrawal. This chart illustrates some of those effects.

PHOTO BY SOURCE: U.S. DRUG ENFORCEMENT ADMINISTRATION, NATIONAL INSTITUTE ON DRUG ABUSE

Effects of oxycodone: The high caused by oxycodone and other opiates affects nearly every major organ in the human body. So does withdrawal. This chart illustrates some of those effects.

Oxy's out. Roxies rule.A tiny blue pill, no bigger than a baby aspirin, overshadows nearly every other illegal drug on the market in East Tennessee. Men and women beg, haggle, threaten, lie, steal and kill — all for a handful of pills.

"It's the new crack," Knox County Sheriff's Office Lt. John Hopkins said. "Most of the addicts we see don't even shop for Oxys now. They've all switched to Roxies, and it's worse than crack ever was."

Doctors, police and emergency workers see the fallout every day. Sometimes it's a pill-sick addict who steals today to buy tonight's fix. Sometimes it's a baby born shaking with seizures from withdrawal.

Oxycontin: A time-release form of oxycodone, an opioid painkiller, produced by Purdue Pharma and used to treat chronic pain. Strengths range up to 80 mg per pill. Nicknames include Oxys, O's and hillbilly heroin.

Roxicodone: Instant-release form of oxycodone produced by Xanodyne Pharmaceuticals and used to treat breakthrough pain. Strengths range up to 30 mg per pill. Nicknames include Roxies, blues and stars.

Opana: Time-release form of oxymorphone, a synthetic opioid, produced by Endo Pharmaceuticals. Nicknames include stop signs, biscuits, octagons and Mrs. O.

Methadone: Synthetic opioid, typically prescribed in pill or wafer form, used to treat pain and to ease withdrawal symptoms for opiate addicts.

Percocet, Endocet, Roxicet: Mixtures of oxycodone and acetaminophen.Percodan, Endodan, RoxiprinMixtures of oxycodone and aspirin.

Vicodin, Lortab, Lorcet: Mixtures of hydrocodone and acetaminophen. Nicknames include Vikes and hydros.

Fentanyl: Synthetic opioid, stronger than morphine, typically prescribed in patch or lollipop form. Nicknames include china white and perc-a-pop.

Xanax: Brand name of alprazolam, a benzodiazepine produced by Pfizer and used to treat panic, anxiety and insomnia. Strengths range up to 2 mg. Nicknames include footballs and totem poles.

Valium: Brand name of diazepam, a benzodiazepine produced by Roche and used to treat panic, anxiety and insomnia. Strengths range up to 10 mg.

Klonopin: Brand name of clonazepam, a benzodiazepine produced by Roche and used to treat panic, anxiety and insomnia. Strengths range up to 2 mg.

Ambien: Brand name of zolpidem tartrate, a sedative produced by Sanofi-Aventis. Strengths range up to 10 mg.

Suboxone: Combination of buprenorphine and naloxone, used to treat opiate withdrawal.

Sometimes it's a corpse — a dealer killed for pills or an addict who chased the last high off the edge of oblivion.

Oxycodone hydrochloride tablets sell at the pharmacy counter under the brand name Roxicodone and offer quick relief from chronic pain for the old, the aching, the crippled and the dying.

Roxies sell on the street for as much as $30 per pill and offer a high that tops crack, heroin or meth — all without the pesky time-release formula that coats Oxycontin, the drug's sister medication.

"It's the epidemic of the day," Knoxville Police Chief David Rausch said. "Everything is attached to it now. Our investigators will tell you that 90 percent of the folks we see who've committed a crime say it's to get their medicine. That's what they call it — medicine.

"The days of the crack dealer on the corner are slowly waning. It's become the medicine dealer on the street."

Drugs of choice

Three people died last year in South Knox County when two men broke into a former police officer's house to steal legally prescribed painkillers. Police say a North Knoxville man's stepson beat him and his wife to death in August to steal pain pills, then burned down the house to cover up the crime.

A rash of drugstore robberies last fall and winter set a local record. Semiannual drug roundups keep rural jails packed and court dockets clogged.

Officers on the beat report dealing with addicts desperate to avoid jail and the agonies of withdrawal. Sometimes they run. Sometimes they fight.

"We're out here beating the bushes today, and in a few months we'll be out here again doing the same thing," said Capt. David Honeycutt, chief investigator for the Claiborne County Sheriff's Office, as he headed out with a stack of indictments in another drug roundup. "Pills have changed the face of law enforcement. It used to be pot, maybe Valium. Now it's pain pills, and they're crazy as hell on them. You'd be hard-pressed to find a family that's not been hurt by these drugs."

Tennessee topped the nation last year in busts of methamphetamine labs, where addicts churn out toxic waste breaking down cold and sinus pills to produce a homemade stimulant. Meth hasn't gone away, but police say they spend more time and money now fighting to keep the cap on the prescription bottle.

"People are afraid of meth, because everybody doesn't do meth," Newport Police Chief Maurice Shults said. "Everybody doesn't do crack. But everybody's on pills of some kind. Pills come from a doctor. People see that as safe. A doctor gives them out, so they've got to be good."

From Oxy to Roxies

Purdue Pharma's Oxycontin tablets once stood as the gold standard for opiate abusers, with concentrated doses of up to 80 mg of oxycodone locked inside a time-release formula easy to crack. Addicts crushed the pills to powder, then snorted or injected them to turn 12 hours of pain relief into an instant high.

That golden egg gained an extra shell when Purdue introduced a new formula last year meant to cut down on abuse. The second-generation Oxys come wrapped in a sticky gelcap coating that burns nostrils and resists the needle.

Some addicts claim to have found ways to beat the coating. Most don't bother.

Roxicodone and its generic equivalents deliver smaller doses of the same drug to treat the short, sharp bursts of breakthrough pain that plague cancer patients and others between round-the-clock doses of painkillers like Oxy. The pills come in 15 mg and 30 mg strength with no gelcap and no time-release coating, ready to deliver instant relief — or an instant high.

"There's no preparation," said Officer Phil Jinks of the Knoxville Police Department's Repeat Offender Squad. "It's straight out of the bottle."

The easy access and potential for profit have caught on among young and old.

"We're dealing with kids in high school, and we've got people retirement age selling," KCSO Sgt. Chris Bryant said. "Pills are easy to get for kids. We've given several drug education classes to teachers, and the first question is always, 'What are those little blue pills we keep seeing?' Those are Roxies."

Some officials expect the problem will only get worse. Opana, a time-release form of oxymorphone introduced five years ago, and fentanyl, a painkiller 100 times more powerful than morphine, offer a stronger high than the old Oxycontin with an even greater potential for overdosing.

Meanwhile, addicts keep working on ways to crack the new Oxys.

"Any time there's a chemical change, there's somebody out there who can alter the effects of that change," Hamblen County Sheriff Esco Jarnagin said. "I don't think you can stop these people from doing what they're doing. The only thing you can do is try to slow them down."

Addiction's Brain Abnormalities Can Be Reversed

 

 

Researchers from the University of Minho in Portugal have discovered that rats exposed before birth to glucocorticoids (GC) not only show several brain abnormalities similar to those found in addicts, but become themselves susceptible to addiction (the glucorticoids, which are stress hormones, were used to mimic pre-natal stress).  But even more remarkable, Ana João Rodrigues, Nuno Sousa and colleagues were able to reverse all the abnormalities  (including the addictive behavior) by giving the animals dopamine (a neurotransmitter/ brain chemical).  The study has several implications – for a start it alerts for the dangers of high levels of stress during pregnancy, but - since GC are often prescribed as an anti-inflammatory or to help organ maturation during pregnancy - it also calls for an urgent investigation on the effects of this drug in pregnant women. But it is what we learn about addiction that is most interesting - the work not only unveils stress as a new susceptibility factor for the disease, but  also a very simple treatment that, if translated into humans, could one day mean an effective treatment, and maybe even the prevention of human addiction.  Drug addiction was for a long time a character flaw, a moral problem. Now, instead,  is accepted as the complex brain disease that is with the addict a patient in need of treatment. After all many people try drugs, but only a few become addicts And it is in these few that lays the key to the disease and its treatment. So what do we know about these patients and the disease? First although the psychological and social contexts in which the drug is taken are important,  as much as 50% of the compulsion is in the  individual’s genetic makeup. We know that addiction is linked to the mesolimbic system - the brain area that evolved to provide feelings of pleasure to actions that increase our survival chances, such as eat, sex and social stimulation. In fact, drugs activate the mesolimbic circuit too, only far stronger than any physiologic stimulus.  This leads to the production of very high quantities of dopamine – the brain chemical linked to pleasure – creating the euphoria that brings users back. After while, though, the brain no longer can cope with the constant ” high” and adapts by becoming desensitised to dopamine (produced by any type of stimulus) what leads users to consume more in order to “feel” again and trapping those more susceptible in addiction. And with the brain changes induced by drugs being apparently long-lasting - since both cravings and relapses don’t disappear with time – it is not easy to escape once trapped. Adding another piece to the puzzle, recently the disease was also linked to stress during crucial developmental periods, such as feotal life. In fact, high levels of prenatal stress increase propensity to mental problems and now have been suggested also to substance abuse, with the effects being mediated by glucocorticoids (GC).    Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 Rodrigues and Sousa’s group have a long history of interest in stress and have seen before that  rats from mothers injected with GC while pregnant (mimicking pre-natal stress) show changes in their mesolimbic area and in the dopamine response. So in the study now published, following these results and the addiction-stress link, the researchers investigated the responses to drugs in rats exposed to GC while in the uterus. These rats were found to have a susceptibility to addiction not present in control (non-exposed) rats. When their mesolimbic system was examined they also showed several structural and molecular abnormalities,  including less dopamine. The levels of their dopamine receptor Drd2, despite initially being very high, once they experimented drugs, went to abnormally low levels . So why is this important? Because reduced dopamine and Drd2 levels are typical of addicts suggesting that stress and long-term exposure to drugs affect the brain in very similar ways what could explain why the first could lead to the second.  Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 The good news is that low levels of dopamine can be treated so Rodrigues and colleagues restored the rats’ dopamine levels to normal just to find,much to their surprise, that all the structural and molecular abnormalities induced by prenatal GC were reversed. Even more surprising, the addictive behavior also disappeared. Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 As Ana João Rodrigues explains, “This is a remarkable result because it suggests that with a relatively simple pharmacological approach- restoration of dopamine levels- we can eventually treat, and even more importantly, potentially prevent drug abuse in vulnerable individuals. Of course that we still have a long way to go but our results are quite promising. In fact, if we know where susceptibility to substance abuse lies – and low dopamine and altered Drd2 response seems to be it - then maybe we can find better ways to prevent/treat this disorder. “ Restoring dopamine levels has been used to treat cocaine cravings but the few trials looking at its effect on addiction were never very clear. One possible reason might be the length or the dosages used – in Rodrigues’ study, rats treated for 3 days reverted back to an addictive behavior 3 weeks after the end of the treatment,  but this no longer occurs if the treatment continues for 3 weeks Now it will be necessary to test this new theory in humans what could be problematic with addicts as they are notoriously not the most cooperative or reliable research subjects. Large human studies on the effect of prenatal stress are also difficult to mount but there are a couple of them being run at the moment that could be tagged into such as “Project Ice Storm” in Canada.This study is following women pregnant n January 98 in southern Québec during an extreme ice storm that led to electrical power failures affecting more than 3 million people for as much as 6 weeks during the coldest month of the year(when temperatures can go to -18 C).  It is still early for any studies on addiction(the children are only 13 years old after all) but it will be an interesting place to look, especially since abnormal levels of behavioral and cognitive problems have already been detected by scientists. Drug abuse and addiction carry enormous social and financial costs to society, families and individuals.Only in the US, the National Institute for Drug Abuse calculates that more than600 billion dollars are being spent, annually, to combat the disease. Despite this,a steady increase of drug use among teenagers and in prescription drugs continues with treatments remaining as inefficient as ever.  Rodrigues and Sousa’s work might be the first step towards a solution if their remarkable results can be translated into humans.

UC Berkeley researchers pinpoint areas of brain linked with addiction

 

Researchers at UC Berkeley have determined the specific areas of the brain that value and interpret decisions, which they hope may lead to new treatments for individuals who struggle with addiction. By measuring the neural activity of macaque monkeys, researchers were able to pinpoint the two specific ways the brain makes decisions, which they explained in a study published Sunday in the journal Nature Neuroscience. They now understand that neural activity in the brain’s orbitofrontal cortex determines the value of decisions, while neural activity in the anterior cingulate cortex evaluates the difference between expectations and results, which is responsible for future behavior. “The brain is basically a computer, and the neuron is taking information and then giving information that they’ve calculated,” said Jonathan Wallis, associate professor of psychology at UC Berkeley and the principal investigator of the study. “This is the first time we’ve been able to show the specific computation to decision-making in specific areas of the brain. That was really the novelty.” While previous research has determined that these sections of the brain are dysfunctional in addicts, the new research explains how the damage leads to addiction. If these parts of the frontal cortex are impaired, addicts lack the signals that provide them with accurate information about how valuable a choice is, making it less likely that they will learn the consequences of their actions, according to Wallis. “If you’re an addict and this area is impaired, you may not realize your goals, and you potentially are not going to learn from unhealthy decisions,” Wallis said. Wallis and his team conducted the research by testing the neural activity of macaque monkeys as they played games that gauged their ability to make decisions. Researchers could measure the calculations that the monkeys were making in the different areas of the brain, which mimicked the way that humans make decisions. The researchers completed the experiment in 2006 and have spent the last five years analyzing the data. Although still a few steps in the future, the ultimate goal of the study is to use the results to treat for individuals with addictions. “Besides therapy, there is nothing we can do for someone that is severely addicted,” Wallis said. “So far no surgical or pharmaceutical treatments exist. By figuring out what is going on when healthy people are making decisions, we can figure out what is going wrong when addicts make bad decisions and find some ways to target these specific areas of the brain.” While the study has led to a greater understanding of how the brain values decisions, researchers will still need to further investigate how addictive drugs are valued in order to develop more effective treatments, according to Howard Fields, professor of neurology and director of the Wheeler Center for the Neurobiology of Addiction at UC San Francisco. “This is a new and important scientific advance,” Fields said. “It is likely that addiction involves dysfunction of the relation between valuation of outcomes and subsequent decision making. In other words, drugs become overvalued compared to other action outcomes. Only by understanding the relation of valuation to action selection will we fully understand how drugs become addictive. After we do that, we’ll be able to develop more effective treatments.”

Drug That Killed Michael Jackson "Was Self-Injected"

 

The jury hear evidence that MJ had also taken a large number of sleeping pills… 08:42, Sunday, 30 October 2011 The last defence witness in the trial of Dr Conrad Murray, Michael Jackson’s personal physician, has told the courtroom that he believed the star was responsible for his own death.   Dr Paul White told jurors that the most likely cause of death was self-injection of a fatal dose of the anesthetic Propofol, after Murray had already administered a small amount. "With the administration of the additional 25 milligrams that we're speculating was self-injected by Mr Jackson, the level increases rapidly and at the time of death would be almost identical to the level found in the urine at autopsy," Dr White said. He revealed that the superstar also appeared to have taken a large dose of sedatives – eight Lorazepam tablets – earlier in the night without Murray’s knowledge. White said that mixing the two drugs would be deadly. "The combination effect is potentially profound." Earlier this week a specialist testified that Michael may have also been addicted to the painkiller Demerol, and was also a regular user of Botox. Murray is charged with involuntary manslaughter into the star’s untimely death in June 2009. The prosecution has already presented four weeks of evidence so it won’t be long before the jurors retire to decide the verdict. Michael’s sister Janet Jackson recently postponed tour dates in Australia in order to be in LA when the verdict is announced. She explained her decision in a statement: "When I planned these shows, the schedule in California was completely different. After talking with my family last night, I decided we must be together right now.”

resumption of heavy drinking killed the singer, who was best-known for her tall beehive hairdo and Grammy-winning album "Back to Black."

Amy Winehouse died from alcohol poisoning, says coroner

Amy Winehouse

 (Credit: Ian Gavan)

 

(CBS/AP) "Death by misadventure." That was an English coroner's curiously quaint way of saying Amy Winehouse drank herself to death. The troubled singer was found with empty vodka bottles in her room and more than five times the legal limit for drinking in England, coroner Suzanne Grennaway said on Wednesday.

 

Winehouse was 27 when she was found dead in her London home on July 23. She had fought a long and public battle with drug and alcohol abuse, and some speculated she died from a drug overdose. But a pathologist said the small amount of a drug prescribed to curb symptoms of alcohol withdrawal had nothing to do with her death.

 

Instead, a resumption of heavy drinking killed the singer, who was best-known for her tall beehive hairdo and Grammy-winning album "Back to Black."

 

Winehous's blood contained 416 milligrams of alcohol per 100 milliliters at the time of her death, pathologist Suhail Baithun said. That equals a a blood alcohol level of 0.4 percent. The British and U.S. legal drunk-driving limit is 0.08 percent.

"Many people don't realize that alcohol can kill you if taken in large enough doses," substance abuse expert Dr. Scott T. Walters, professor of behavioral and community health at the University of North Texas Health Science Center, told CBS News in an email. A depressant, alcohol can slow vital functions like breathing and heart rate to the point they stop.

 

There is no minimum dose for acute alcohol poisoning and the condition varies depending on a person's age, gender, and weight. In recent years, the 5-foot-3-inch Winehouse had appeared extremely thin.

Walters wouldn't speculate on the particulars of Winehouse's death but said a 110-pound woman could reach a potentially lethal blood-alcohol level by downing about 15 ounces of vodka within an hour's time.

 

Winehouse joins a long list of celebrities who died after fighting alcohol problems, including jazz great Billie Holiday, AC/DC lead singer Bon Scott, film legend Richard Burton, writers Dylan Thomas and Jack Kerouac, and country music pioneer Hank Williams.